Antox® and Bactofort® Improved Alterations in Oxidative Stress Biomarkers Induced by a Very Virulent Infectious Bursal Disease Virus in ISA Brown Chicks
Keywords:Antox®, Bactofort®, Infectious bursal disease,, Oxidative stress biomarkers
This study investigated the ameliorative effects of Antox® and Bactofort® on some oxidative stress biomarkers in ISA Brown chicks inoculated with a vvIBDV. Two hundred one-day-old ISA Brown chicks were assigned into four groups of 50 birds each. Groups A and B were supplemented with Antox®, and Bactofort® respectively from 1 to 42 days of age, and inoculated with vvIBDV at 28 days of age, while C and D served as positive and negative controls. Sera collected from chicks at 1, 14, 28, 35, and 42 days of age were analyzed for activities of superoxide dismutase (SOD), catalase (CAT), glutathione perioxidase (GPx), malondialdehyde (MDA) concentration, and erythrocyte osmotic fragility (EOF). Results revealed significantly (p < 0.05) increased SOD activity, decreased CAT and GPx activities, decreased MDA concentration and EOF in groups administered Antox®, and Bactofort® compared to positive control at 7 (day 35) and 14 (day 42) days post-inoculation. In conclusion, Antox® and Bactofort® ameliorated the deleterious effects of vvIBDV on SOD, CAT and GPx activities, MDA concentration, and EOF. Antox® and Bactofort® could be used to ameliorate vvIBDV-induced oxidative changes and further studies should be carried out to determine their possible adverse effects when administered for preventive purposes.
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